Our Scientific Solutions

Cancer On Chip

An advanced platform for studying the complex interactions between cancer cells and their microenvironment

A more accurate and efficient approach for studying the mechanisms behind cancer growth and progression. This cutting-edge technology provides a potent platform for investigating the complex interactions between cancer cells and their microenvironment in a controlled environment.

With our innovative Cancer-on-Chip precision and accuracy are improved, leading to accelerated drug discovery timelines and improved outcomes.

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Tissue Models Options
CANCER-ON-CHIP
Monolayer231

2D cells monolayers

Histology

Matrix based tumor models

Spheroids, Organoids

Patient derived biopsy

Patient derived Biopsies

Applications

Drug Screening

Personalized Medicine

Cancer Cell Migration and Invasion

Tumor to Metastatic Target

Tumor Microenvironment

Immuno-Oncology

3D-flowGel

Super-fast, highly flexible, and reproducible, it’s a ready to use 3D cell culture hydrogel that closely resembles the extracellular matrix (ECM).

Easily move to 3D cell culture

Permissive to chemical functionalizations, stable over time, and mechanically tunable, 3D-flowGel allows optimization of the in vitro cell culture in a 3D fashion, encouraging long-term cell viability, selective migration, and protein secretion. Due to its chemical composition, 3D-flowGel supports an extensive spectrum of downstream analysis through an easy and fast cell recovery.
Moreover, 3D-flowGel recapitulates the in vivo tissue barrier conditions for more predictive diffusion of molecules, nanoparticles and drugs under testing.

Discover more >

POSSIBLE READOUTS

Cancer-on-Chip Model

A more realistic and physiologically relevant environment for more predictive readouts

CITOTOXICITY

By measuring cell viability and apoptosis, our cytotoxicity readout reveals how effectively new therapeutic compounds target and kill cancer cells. This robust platform accelerates drug development, identifying promising candidates for clinical trials.

Cells Intravasation

CANCER CELLS SPREADING & METASTATIZATION

Measuring cancer cell spreading in a humanized platform provides valuable insights into their metastatic potential in new tissues and identifies key molecular pathways involved in this process.

Molecular Analysis

OMICS STUDIES

Providing valuable insights into disease pathways, identifying new drug targets, and developing personalized medicine approaches, while offering an effective means of characterizing the cellular and molecular effects of novel compounds or treatments.

PHENOTYPE CHARACTERIZATION

CANCER CELLS PHENOTYPE CHARACTERIZATION

Utilizing state-of-the-art flow cytometry, our platform offers comprehensive phenotype characterization of cancer cells, providing detailed insights into surface marker expression, cell cycle status, and apoptosis on specific cancer cell populations (i.e. circulating cancer cells, infiltrated cells)

drug efficacy millifluidic research react4life

DRUG EFFICACY

We measure key parameters such as cell viability and apoptosis to determine the effectiveness of new compounds like chemotherapeutic agents, targeted therapies, and immunomodulating agents. By leveraging advanced techniques, we evaluate how different drug classes impact cancer cells, providing critical data to support the development of next-generation cancer treatments.

Immuno Oncology IMMUNE CELLS INFILTRATION

IMMUNE CELLS INFILTRATION

Our platform enables the detailed analysis of immune responses, including the infiltration of T cells, NK cells, and macrophages, as well as the activation status of these immune cells. By simulating the interaction between cancer cells and the immune system, we provide critical insights into the efficacy of immunotherapies, checkpoint inhibitors, and other immune-modulating treatments.

References

Marzagalli M et al, Front. Bioeng. Biotechnol. 2022 – A multi-organ-on-chip to recapitulate the infiltration and the cytotoxic activity of circulating NK cells in 3D matrix-based tumor model

Vitale C et al, Cancers 2022 – Tumor Microenvironment and Hydrogel-Based 3D Cancer Models for In Vitro Testing Immunotherapies

Zimmer J et al, Frontiers in Immunology 2021 – Recent 3D Tumor Models for Testing Immune-Mediated Therapies

Marrella A et al, Altex 2020 – 3D fluid-dynamic ovarian cancer model resembling systemic drug administration for efficacy assay

Marrella A et al, Front. Immunology 2019 – Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

Cavo M et al, Sci Rep. 2018 – A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo”

European Projects

PRESSURE Project

Preventing Therapy Resistance in Esophageal Cancer Treatment.

B2B Project

Modeling Spontaneous Breast Cancer Metastasis to the Bone.

Mac4Me Project

Macrophage Targets for Metastatic Treatment.

Past Webinars

Explore our webinars where esteemed clients, partners and high-level researchers, present groundbreaking data obtained using our MIVO technology for cancer applications.

In Our Laboratory

Supporting you with a testing service.

In Your Laboratory

Internal adoption of technology.

Work Together

Optimizing protocol assay for you.

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