Our Scientific Solutions
Skin On Chip
A novel Skin-on-Chip Model for permeation and absorption studies
By mimicking the structure and function of the skin in a controlled and dynamic environment, our skin-on-chip model provides a powerful tool for studying the skin’s response to various stimuli, including drugs, toxins, and environmental factors.
This Skin-on-Chip model provides a more realistic, completely humanized and physiologically relevant environment that better mimics the in vivo conditions for studying the effect of different cosmetic and pharmaceutical products on the skin and developing more accurate and personalized treatments for various skin diseases. Its innovative configuration is designed to comply with OECD 428 for in vitro skin absorption testing and can also be adapted for cosmetic and medical device applications.
Tissue Models Options
SKIN-ON-CHIP
Biomimetic membranes
2D cells monolayers
3D Reconstructed tissues
Biopsies
Applications
Claim Substantiation
To objectivate, validate and support product claims with scientific evidence through precise, reliable and reproducible testing on humanized models.
Efficacy Testing
To test the efficacy of active ingredients or formulations for cosmetics and medical devices, studying how they interact with human skin cells.
Mechanistic Insights
To gain a deep understanding of how bioactive molecules function in human body, studying their pathways and effects at a cellular level.
OECD 428
To perform transdermal absorption studies in accordance with OECD 428 guidelines, providing reliable and regulatory-standard data for safety assessments
Pre-screening
To screen and select the most promising molecules before animal or human testing, offering valuable data for product development while saving time and costs.
Toxicity Testing
To identify potentially harmful effects on specific organs, including evaluating cytotoxicity from the dosage of natural ingredients, mitigating risks.
Example of Assays
- TRANSDERMAL TRANSPORT
- SKIN AGING
- SKIN INFLAMMATION
- HYDRATION & ANTI-GRAVITY
- SKIN-IMMUNE RESPONSE
- BACTERIA CO-CULTURE
- GUT-SKIN AXIS
- HYPERPIGMENTATION
- SKIN IRRITATION
- WOUND HEALING
READOUTS
Skin on Chip
PERMEATION FRACTION
CYTOTOXICITY ASSESMENT
EFFICACY ASSAYS
Skin on chip supports not just a single type of quantitative measurement, but enables multiple parallel measurements at analytical, biological, and molecular levels.
TEER MEASUREMENTS
HYDRATION MARKERS VIA IMMUNOFLUORESCENCE
INFLAMMATION RESPONSE
References
Pulsoni I et al, SLAS Technology, 2022 – Comparison Between Franz Diffusion Cell and MIVO, a novel Micro-physiological System for In Vitro Penetration Assay Using Different Skin Models. Read now >
Peñuela L et al., Exp Dermatol., 2018 – Atomic force microscopy for biomechanical and structural analysis of human dermis: A complementary tool for medical diagnosis and therapy monitoring. Read now >
EuroCosmetics 2028/26 – Testing the Future. Read now >
Cosmetic Technology 2018/21(2) – Anti-pollution: innovativo test in vitro per quantificare il particolato che entra nel nostro corpo. Read now >
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