Tumor Cells Invasion Assay

The Tumor Cell Invasion Assay is designed to evaluate the metastatic potential of cancer cells by assessing their ability to migrate from a primary tumor mass into a simulated circulatory system. This assay is crucial for understanding early metastasis and for testing novel anti-metastatic therapies.

Purpose of the Test

This assay integrates advanced three-dimensional tumor models with a dynamic fluidic environment that mimics systemic circulation. Its primary objective is to quantify the rate and extent of tumor cell invasion from the primary tumor into the bloodstream. By replicating the physical
and biochemical conditions found in vivo, the assay provides a predictive measure of metastatic behavior and helps to evaluate the efficacy of anti-metastatic agents.

In line with guidelines from regulatory agencies, this assay is a key component in the preclinical assessment of new cancer therapies. Its rigorous design ensures that comprehensive data on tumor cell dissemination are collected, supporting the development of safer and more effective anticancer treatments.

The MIVO® Advantage: A Superior Predictive Model

By incorporating a dynamic fluidic system, this assay overcomes the limitations of static models. The continuous flow simulates physiological shear stress and fluid dynamics, which are critical factors influencing tumor cell migration in vivo. This approach not only enhances the realism of the assay but also provides more reliable data
that closely correlate with clinical metastatic progression.

Our Unique Value Proposition

Physiologically Relevant 3D Tumor Microenvironment: The assay uses a three-dimensional tumor model that accurately reproduces the architecture and cell–cell interactions of a primary tumor, thereby offering a realistic platform to study invasion.

Dynamic Fluidic Simulation: The integrated fluid system replicates the circulatory forces and physical conditions of the bloodstream, promoting the migration of tumor cells from the primary mass into the simulated vascular compartment.

Quantitative Invasion Metrics:The platform delivers robust, quantitative measurements of tumor cell dissemination, enabling precise evaluation of the metastatic process and optimization of therapeutic interventions.

Predictive of Metastatic Potential:By modeling the early steps of metastasis, the assay provides critical insights into tumor cell behavior, informing both drug discovery and personalized treatment strategies.