Cancer cell plasticity represents the basis for cancer progression. Let’s think about the ability of cancer cells to grow within different niches: these cells are so adaptable that are able to grow in their original tissue, as well as in metastatic sites, even if histologically very different. Similarly, they can adapt to adverse stimuli, such as the attack launched by the immune system, or the anticancer therapies. Cancer stem cells represent the most relevant example of cancer cell plasticity. Their phenotype can be shaped depending on the surrounding microenvironment and, from an experimental point of view, depending on the [...]
Our CEO, Maurizio Aiello will partecipate as speaker at the 2021 edition of the JRC Virtual Summer School on Non-animal Approaches in Science organised by the European Commission's Joint Research Centre (JRC) and its EU Reference Laboratory for alternatives to animal testing (EURL ECVAM), while our Biomedical engineer Ilaria Pulsoni will partecipate as attendee. To further informations we invite you to visit the official page of European Commission here: https://ec.europa.eu/jrc/en/event/conference/jrc-summer-school-non-animal-approaches-science-3
She has been with us for just over a year. She is head of internal and external communication of the company and the marketing activities. Today we present Giulia, our brand manager. Giulia, it seems like yesterday that we started working together but a year has already passed. We speak your language: can you tell us the “strengths and weaknesses” of your experience in React4life? Let's start with the weaknesses: joining a biotechnology company was not easy at the beginning, as it required a great cultural effort. Organ-on-chip, organoids, cell culture, In-vitro test, principle 3R were concepts almost unknown [...]
The development of new research methods for drug analysis represents one of the most significant aspects of drug development. However, this complicated process still faces some challenges from significant issues such as time consumption, low-throughput, poor reliability and standardization, high cost. The traditional 2D static culture in most cases do not predict the in vivo response as they cannot resemble properly the tissue physiological environment. Therefore, the need of combining the fluid physics along with three-dimensional cell compartmentalization has led to the development of novel in vitro system such as lab on chip and microphysiological systems (MPS) like MIVO®. [...]
Interview with Future and Emerging Technologies Innovator Silvia Scaglione from the Eruopean Commission website https://ec.europa.eu/digital-single-market/en/news/interview-future-and-emerging-technologies-innovator-silvia-scaglione which we thanks. Silvia Scaglione is specialist in bioengineering. Since 2010, she is a permanent researcher at the Italian National Research Council (CNR) and head of the Labor atory of Tissue Engineering CNR-IEIIT in Genoa. She is also founder, president and chief scientist of React4Life, an innovative biotech start-up. Currently, Silvia Scaglione is coordinating the B2B project, which is supported by the FET Open programme under the Horizon 2020 Framework. B2B (in full title “Modeling spontaneous Breast cancer metastasis TO the Bone with a first-of-its-kind [...]
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