Anti-itching lenitive activity
Pruritus, or itching, is a complex and multifaceted sensation, often driven by key inflammatory mediators. This assay provides a validated and reliable method for assessing the safety and efficacy of anti-pruritic formulations, assessing their ability to modulate inflammatory pathways and alleviate discomfort.
Purpose of the Test
The MIVO-based anti-itch test uses the Skin-on-Chip platform, to replicate human skin structure and function and precisely evaluate soothing efficacy of testing formulations, by measuring their impact on LTB4 production, a critical driver of inflammation and itching.
The MIVO® Advantage: A Superior Predictive Model
The MIVO® organ-on-chip technology revolutionizes traditional 3D models by introducing dynamic fluid flow (Pulsoni et al. 2022), creating a highly realistic simulation of physiological conditions. This innovative platform enables precise biomarker analysis, such as LTB4, while capturing complex cell interactions. MIVO® offers a predictive and reliable tool for evaluating anti-inflammatory and soothing effects with unparalleled accuracy.
Our Unique Value Proposition
Anti-itching Assay
In summary
READOUTS
- Epithelial barrier integrity (TEER measurement)
- Histology
- Inflammation (i.e. LTB4)
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