A Tri-Cell Culture Model of Human Intestine Constructed on Electrospun Polyurethane Scaffold Inserts in the MIVO^® Millifluidic Device: Effect of Static vs. Dynamic Flow Culture Conditions

Drug-induced gastrointestinal Toxicity (DIGT) frequently hinders treatments.

Yet current preclinical models – ranging from animal to static 2D/3D cultures- struggle to accurately replicate human physiological conditions or offer rapid reliable assessment.

Pysiological fluid flow induced sher stresses recapitualted within a millifluidic organ-on-chip platform accelerate intestinal cells maturation, functional barrier formation and more effectively simulate human systemic drug exposure than static environments.

- - - - Conference: MPS 2026, Washington
      - Authors: Gergo Borka^1,2, E. Palamà¹, L. Cipolla³, M. Aiello^1,4, S. Scaglione^1,4

¹React4life, Genoa (Italy)
²University of Milano-Bicocca, Milan (Italy)
³Dept. of Biotechnology and Biosciences University of Milano-Bicocca, Milan (Italy)
⁴National Research Council (CNR)

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A Tri-Cell Culture Model of Human Intestine Constructed on Electrospun Polyurethane Scaffold Inserts in the MIVO^® Millifluidic Device: Effect of Static vs. Dynamic Flow Culture Conditions

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