Targeted drug delibery with erythrocyte-derived nanovescicles in an organ-on-chip tumor model

Current cancer therapies primarly target cancer cells but often cause significant damage to hearlthy tissues. Extracellular vescicles (EVs) have emerged as next-generation drug delivery platforms.

We propose an innovative approach utilizing Nanoerythrosomes (NanoEs), artificial erythrocyte-derived vescicles, functionalized with a peptide targeting the tumor-specific EDB-fubronectin, by copper-free click chemistry, and loaded with Paclitaxel (PTX) via sonification.

  • Conference: NanoTME 2025, Enschede, Netherlands
  • Authors: E. Palamà1, M.C. Ciferri 2, M. Aiello1, S.Scaglione1,3, R. Tasso2

1 React4life, Genoa (Italy)
2 University of Genoa, Genoa (Italy)
3 National Research Council (CNR)

Targeted drug delibery with erythrocyte-derived nanovescicles in an organ-on-chip tumor model

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