One of the main issues in biological and medical research is the need of reliable tools for physiologically relevant human modeling. This is particularly true for cancer research, since drug resistance and cancer-related deaths still represent a major challenge. The MIVO technology encloses a fluidic multi-chamber platform that can easily adapt to multiple applications, from the basic biological characterization/targets identification to pharmacological testing, in a humanized in vitro model. MIVO is perfectly customizable, so that the researcher can recapitulate the desired micro-physiological/micropathological system in a well, in order to improve and speed-up basic and pharmacological research.
Cancer stem cells (CSCs) are considered the root of the primary and the metastatic tumor mass, and responsible of drug resistance. Thus, the understanding of CSCs biology represents the basis for the improvement of cancer therapies.
This webinar wants to shed a spotlight on the possible application of the MIVO device in the field of cancer stem cells/cancer cell plasticity: the possibility to shape a reliable cancer model could provide a powerful tool for the study the CSC biology and the pharmacological screening of anticancer drugs.
About the speaker: Dr. Monica Marzagalli Senior Cell Biology Scientist at React4life and Adjunct Professor (Laboratory of General and Cellular Biology), University of Milano
Monica graduated in Drug Biotechnology at the University of Milano, Italy, where she later obtained her PhD in Endocrinological and Metabolic Sciences, in 2015. Since the beginning of her career, her research focused on tumor biology, with emphasis on the cellular and molecular mechanisms of melanoma progression, on its pharmacological targeting and on the characterization of the cancer stem cell-subpopulation. Given her growing interest in the tumor immune microenvironment, in 2017 she flew to Los Angeles, where she worked as a Postdoc at City of Hope National Medical Center, acquiring immunooncology-related skills. Moving back to the University of Milano, she started working on the cross-talk between cancer stem cells and tumor-associated neutrophils, finally landing to React4life as a Senior Cell Biology Scientist.