Our MIVO® – Webinar

Join our webinar about our innovative MIVO® technology

Modelling healthy and leukemic lymphocytes dissemination in-vitro

When: Tuesday 20 July 2021 at 3:00 PM – CET Time
Register here: https://us02web.zoom.us/webinar/register/WN_XDRI6ZIoSX2Pj0nda5G3eQ

With this new webinar we want to answer this question: Why 3D tissue models and microfluidic systems are important for modeling healthy and leukemic lymphocytes dissemination in-vitro? Our guest speaker, Dr. Cristina Scielzo, will talk about her recent reserach in this topic, by adopting innovative approches like microgravity bioreactor and 3D printing; she will also present her preliminar results about the adoption of  MIVO device for culturing lymphocytes.

About the speaker

Dr. Cristina Scielzo received her doctor degree in Medical Biotechnology at Università Vita-Salute San Raffaele and in 2012 obtained her PhD in Physiology at University of Milano. Since 2020 she is Group Leader of the Unit of Malignant B cell biology and 3D modelling at IRCCS Ospedale San Raffaele in the division of Experimental Oncology. She has published >40 articles in peer-reviewed journals. Her work has been cited > 3900 times, with an H-index of 31 and IF > 350.

Her team is currently studying the tumour cell/microenvironment interactions in chronic lymphocytic leukemia (CLL). In parallel, they are developing new advanced 3D in-vitro co-culture systems by prototyping a bench-top 3D bio-printer and exploiting different bioreactors with the goal to establish a 3D multi-organ system to dissect the leukemia/lymphoma-microenvironment cross-talk in the tissues.


In vitro models replicating the human intestinal absorption

When: July 15th , 3:00PM CET / 8:00AM EST.
Register here: https://us02web.zoom.us/webinar/register/WN_x70ZPRVVTmKEh3nu7SP6UQ

Speaker: Silvia Scaglione is a Biomedical Engineer, author of more than 60 peer-reviewed papers on international journals and inventor of 7 patent applications. Silvia is co-founder and Chief Scientists Officer of R4l

Descrizione: the gut absorption of orally administered drugs, food compounds and integrators has gained attention since poor oral bioavailability often led to failures for new drug approval. Different in vitro preclinical models have been recently developed and optimized to better resemble human physiology in the lab. In this webinar, we provide an overview of in vitro models and a focus on a novel fluid-dynamic gut tissue model aimed at mimicking the intestinal barrier for pharmaceutical screening.

Fluid-dynamic multi-in vitro organ (MIVO®) applications for cancer cell plasticity

When: March 30th, 2:30 pm CET / 8:30 am EST.
Register here: https://us02web.zoom.us/webinar/register/WN_vXdBDL4bTSGLlz-zSGqO7w

One of the main issues in biological and medical research is the need of reliable tools for physiologically relevant human modeling. This is particularly true for cancer research, since drug resistance and cancer-related deaths still represent a major challenge. The MIVO technology encloses a fluidic multi-chamber platform that can easily adapt to multiple applications, from the basic biological characterization/targets identification to pharmacological testing, in a humanized in vitro model. MIVO is perfectly customizable, so that the researcher can recapitulate the desired micro-physiological/micropathological system in a well, in order to improve and speed-up basic and pharmacological research.

Cancer stem cells (CSCs) are considered the root of the primary and the metastatic tumor mass, and responsible of drug resistance. Thus, the understanding of CSCs biology represents the basis for the improvement of cancer therapies.

This webinar wants to shed a spotlight on the possible application of the MIVO device in the field of cancer stem cells/cancer cell plasticity: the possibility to shape a reliable cancer model could provide a powerful tool for the study the CSC biology and the pharmacological screening of anticancer drugs.

About the speaker: Dr. Monica Marzagalli Senior Cell Biology Scientist at React4life and Adjunct Professor (Laboratory of General and Cellular Biology), University of Milano

Monica graduated in Drug Biotechnology at the University of Milano, Italy, where she later obtained her PhD in Endocrinological and Metabolic Sciences, in 2015. Since the beginning of her career, her research focused on tumor biology, with emphasis on the cellular and molecular mechanisms of melanoma progression, on its pharmacological targeting and on the characterization of the cancer stem cell-subpopulation. Given her growing interest in the tumor immune microenvironment, in 2017 she flew to Los Angeles, where she worked as a Postdoc at City of Hope National Medical Center, acquiring immunooncology-related skills. Moving back to the University of Milano, she started working on the cross-talk between cancer stem cells and tumor-associated neutrophils, finally landing to React4life as a Senior Cell Biology Scientist.


When: February 18th, 3:30 pm CET / 9:30 am EST.
Register here: https://bit.ly/3qzw4Ms

Do you want to learn more about establishing robust #3Dcellculture models? Subscribe this webinar in collaboration with Obatala Sciences!

About the speakers:
Silvia Scaglione is a biomedical engineering, CSO, head of R&d team and co-founder of React4life.
She is currently author of more than 60 peer-reviewed papers on international journals and inventor on 7 patent applications.
She is also coordinator of a H2020-Future Emerging Technology (FET-OPEN) project about a spontaneous breast-to-bone in vitro metastasis model B2B From breast to bone

Trivia Frazier, PhD, MBA is a native of New Orleans and an experienced Adult Stem Cell Researcher and Biotech Business Professional with 15+ years of experience in basic science research, and management. She holds bachelor’s degrees in Physics and Biomedical Engineering, an MBA with a concentration in Finance, and a PhD in Biomedical Sciences. She completed her postdoctoral training at Pennington Biomedical Research Center and the Tulane Center for Stem Research and Regenerative Medicine. She has trained and collaborated with national and international key opinion leaders and worked with clinicians within the areas of Tissue Engineering and Regenerative Medicine, Breast and Bone Oncology, Obesity, Stem Cell Transplantation, and Diabetes.


When: Jan 21th, 3 pm CET / 9 am EST.
Register here: https://lnkd.in/ex9TyW6

The development of new molecules and innovative therapies is often hampered by unreliable, poor standardized and time-consuming disease models.
During this webinar, Silvia Scaglione, Chief Scientist Officer of #React4life will discuss how MIVO® is a valuable tool for in vitro drug testing. You will learn:
– how MIVO® can be used to culture 3D cancer models and testing the efficacy of drugs;
– how MIVO® supports the culture of 3D cancer models and flowing immune cells to study their cross-talk and test immunotherapies.