MIVO CHIPS
GUT-on-CHIP
The innovative fluid dynamic Gut-on-Chip Model
A new and effective way to test the bioavailability and efficacy of new molecules, more predictive than standard in vitro studies, faster and cheaper than in vivo tests.
Our Gut-on-Chip technology, combined with a monolayer of cells or reconstructed human oral epithelial tissue, is a valuable in vitro tool for studying molecular transport under highly predictive conditions that closely resemble the dynamic in vivo environment. Compared to traditional in vitro tests carried out in static conditions, our technology more faithfully reproduces the physiological environment, allowing for more accurate pre-screening of molecules and safety tests.
Tissue Models Options
GUT-ON-CHIP
Biomimetic membranes
2D cells monolayers
3D Reconstructed tissues
APPLICATIONS
Humanized models to closely resemble the dynamic in vivo environment
ADME studies
Test the absorption, distribution, metabolism, and excretion of new molecules in a more accurate, cost-effective, and ethical manner.
Microbiome research
Study the interactions between the gut microbiome and the immune system, and how they affect overall health.
Toxicology studies
Test the toxicity and safety of various compounds and formulations in the gut environment.
Nutrient absorption
Study nutrient absorption and develop new nutritional interventions for various health conditions.
Disease modeling
Recapitulate various gut diseases such as inflammatory bowel disease, celiac disease, or Crohn’s disease, and study their underlying mechanisms.
Environmental studies
Study the impact of environmental factors on gut health and function, such as exposure to toxins or pollutants.
POSSIBLE OUTCOMES
Gut-on-Chip Model
A more realistic and physiologically relevant environment for more predictive readouts
Kinetic of permeation
The permeability of a set of drugs/molecules is determined by quantifying the compounds’ transport over time, deriving the steady-state flux from the linear part of the cumulative curves and calculating the apparent permeability (Papp)
Cytotoxicity
After the permeation of testing compounds, cell viability is evaluated through a live/dead assay to detect the optimal dose and evaluate the potential cytotoxic effect
Complete Digestion
Simulate the complete digestion in the gastrointestinal tract of the testing compound orally administered using constant ratios of testing substance to different digestive fluids and constrant PH for each step
Publications
Find a selection of publications for research purposes.
Workshops
Find a selection of posters for research purposes.
Webinars
Find a selection of protocols for research purposes.
CONTACT US
We are here for you!
Share with us any questions about placing an order, setting your experiment or learning about our products. We are here to help!