MIVO CHIPS

GUT-on-CHIP

The innovative fluid dynamic Gut-on-Chip Model

A new and effective way to test the bioavailability and efficacy of new molecules, more predictive than standard in vitro studies, faster and cheaper than in vivo tests.

Our Gut-on-Chip technology, combined with a monolayer of cells or reconstructed human oral epithelial tissue, is a valuable in vitro tool for studying molecular transport under highly predictive conditions that closely resemble the dynamic in vivo environment. Compared to traditional in vitro tests carried out in static conditions, our technology more faithfully reproduces the physiological environment, allowing for more accurate pre-screening of molecules and safety tests.

Tissue Models Options
GUT-ON-CHIP
Permeapad Membrane

Biomimetic membranes

2D cells monolayers immune on chip react4life

2D cells monolayers

3D Reconstructed Tissues immune on chip react4life

3D Reconstructed tissues

APPLICATIONS

Humanized models to closely resemble the dynamic in vivo environment

ADME studies

Test the absorption, distribution, metabolism, and excretion of new molecules in a more accurate, cost-effective, and ethical manner.

Microbiome research

Study the interactions between the gut microbiome and the immune system, and how they affect overall health.

Toxicology studies

Test the toxicity and safety of various compounds and formulations in the gut environment.

Nutrient absorption

Study nutrient absorption and develop new nutritional interventions for various health conditions.

Disease modeling

Recapitulate various gut diseases such as inflammatory bowel disease, celiac disease, or Crohn’s disease, and study their underlying mechanisms.

Environmental studies

Study the impact of environmental factors on gut health and function, such as exposure to toxins or pollutants.

POSSIBLE OUTCOMES

Gut-on-Chip Model

A more realistic and physiologically relevant environment for more predictive readouts

KINETIC OF PERMEATION

Kinetic of permeation

The permeability of a set of drugs/molecules is determined by quantifying the compounds’ transport over time, deriving the steady-state flux from the linear part of the cumulative curves and calculating the apparent permeability (Papp)

Cytotoxicity

After the permeation of testing compounds, cell viability is evaluated through a live/dead assay to detect the optimal dose and evaluate the potential cytotoxic effect

COMPLETE DIGESTION

Complete Digestion

Simulate the complete digestion in the gastrointestinal tract of the testing compound orally administered using constant ratios of testing substance to different digestive fluids and constrant PH for each step

Publications

Find a selection of publications for research purposes.

Publications

Workshops

Find a selection of posters for research purposes.

Workshops

Webinars

Find a selection of protocols for research purposes.

Webinars
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