Our Scientific Solutions

Rely on Science

Biotech & Pharma Solutions

Unlock the potential of your research with our state-of-the-art scientific expertise and innovative 3D fluid dynamic cell culture platform. Our approach provides highly predictive, reliable, and robust in vitro data, setting a new standard in the industry.

Pharmacokinetics and Pharmacodynamics (PK/PD) assays are crucial in the development of new molecules. Our advanced MIVO® technology, featuring single and multi-organ on chip systems, optimizes the final composition, dosage, and administration routes of your compounds. This ensures maximum effectiveness while minimizing adverse effects. Our service delivers unparalleled accuracy and reliability, offering faster and more precise data. This ensures that your project remains on track and meets deadlines, allowing you to focus on innovation and discovery.

Utilizing our MIVO OOC systems with different tissues or multi-organ combinations, our in vitro service generates novel insights into the human body’s effect on drugs, medical devices or testing compounds.

Service Journey

Fast and Simple in Just 4 Steps

Design and Finalize Experiment Plan.

Quickly tailor the perfect experiment setup using our cutting-edge MIVO® technology.

Preparation of Organ Models.

Ensures rapid preparation of organ models, ready for immediate use with high precision.

Compound Dosing and Sample Collection.

Benefit from precise compound dosing and seamless sample collection facilitated by our innovative MIVO® systems.

Data Analysis and Reporting.

Receive detailed and reliable reports faster and easier.

Example of Organ Models

Select the organ you wish to study in a fully humanized in vitro environment. If you don’t see the model you need, reach out to our team.
Our R&D department is continually developing new models and may already be working on what you require!

GUT
SKIN

Our advanced gut models simulate the complex environment of the healthy and pathological human gastrointestinal tract to study molecule absorption, intestinal permeability, and bacterial interactions under realistic human physiological conditions.

Our advanced skin model is designed to reproduce various levels of aging under healthy and pathological conditions for advanced studies of efficacy, barrier integrity, permeation, and more, providing comprehensive insights into how new treatments perform under realistic physiological conditions.

Example of Organ Models

Select the organ you wish to study in a fully humanized in vitro environment. If you don’t see the model you need, reach out to our team.
Our R&D department is continually developing new models and may already be working on what you require!

GUT

Our advanced gut models simulate the complex environment of the healthy and pathological human gastrointestinal tract to study molecule absorption, intestinal permeability, and bacterial interactions under realistic human physiological conditions.

Model: Intestine

Application: Absorption

Readout: Fraction of permeated compound across gut tissue model.

Model: Oral Gastric Intestine

Application: PBPK

Readout: Different fractions of digested and permeated compound.

Model: Leaky Gut

Application: Mode of action/efficacy

Readout: Permeability, TEER.

Model: Gut-Immuno

Application: IBD

Readout: Istology, immunohistochemistry, TEER, permeability, cytokines profiles.

Model: Gut-Brain

Application: Serotonin release, GABA production.

Readout: Therapeutic effect.

Model: Gut-Liver

Application: ADME

Readout: Fraction of permeated and metabolized compound.

Model: Gut-Bacteria

Application: Mode of action/efficacy

Readout: Probiotic adhesion, TEER, short chain fatty acid quantification.

SKIN

Our advanced skin model is designed to reproduce various levels of aging under healthy and pathological conditions for advanced studies of efficacy, barrier integrity, permeation, and more, providing comprehensive insights into how new treatments perform under realistic physiological conditions.

Model: Skin

Application: Hydration

Readout: Istology, immunohistochemistry, TEER.

Model: Skin-Tumor

Application: PK/PD

Readout: Skin permeation and anticancer efficacy.

Model: Skin

Application: Permeation

Readout: Fraction of permeated compound.

Model: Skin

Application: Inflammation

Readout: Pro-inflammatory cytokines profiles

Model: Skin

Application: Aging

Readout: Istology, immunohistochemistry, TEER, matrix protease quantification.

Model: Skin

Application: Wound Healing

Readout: Istology, immunohistochemistry, TEER.

Model: Intestine

Application: Absorption

Readout: Fraction of permeated compound across gut tissue model.

Model: Oral Gastric Intestine

Application: PBPK

Readout: Different fractions of digested and permeated compound.

Model: Leaky Gut

Application: Mode of action/efficacy

Readout: Permeability, TEER.

Model: Gut-Immuno

Application: IBD

Readout: Istology, immunohistochemistry, TEER, permeability, cytokines profiles.

Model: Gut-Brain

Application: Serotonin release, GABA production.

Readout: Therapeutic effect.

Model: Gut-Liver

Application: ADME

Readout: Fraction of permeated and metabolized compound.

Model: Gut-Bacteria

Application: Mode of action/efficacy

Readout: Probiotic adhesion, TEER, short chain fatty acid quantification.

Model: Skin

Application: Hydration

Readout: Istology, immunohistochemistry, TEER.

Model: Skin-Tumor

Application: PK/PD

Readout: Skin permeation and anticancer efficacy.

Model: Skin

Application: Permeation

Readout: Fraction of permeated compound.

Model: Skin

Application: Inflammation

Readout: Pro-inflammatory cytokines profiles

Model: Skin

Application: Aging

Readout: Istology, immunohistochemistry, TEER, matrix protease quantification.

Model: Skin

Application: Wound Healing

Readout: Istology, immunohistochemistry, TEER.

VAGINA
JOINT

By simulating the unique environment of vaginal tissue, we can accurately evaluate the effectiveness and safety of new treatments under physiological conditions, also reproducing different levels of aging and damage from viral or bacterial lesions.

With our advanced joint models, it is possible to study the method of action and efficacy of various treatments, accurately assessing how therapies affect joint health and development under realistic physiological conditions.

VAGINA

By simulating the unique environment of vaginal tissue, we can accurately evaluate the effectiveness and safety of new treatments under physiological conditions, also reproducing different levels of aging and damage from viral or bacterial lesions.

Model: Gynecologic cancer

Application: PD, Efficacy

Readout: Dose response curve

Model: Vagina

Application: Hydration

Readout: Istology, immunohistochemistry, TEER.

JOINT

With our advanced joint models, it is possible to study the method of action and efficacy of various treatments, accurately assessing how therapies affect joint health and development under realistic physiological conditions.

Model: Cancer Joint

Application: Mode Of Action/Efficacy

Readout: Occurrence of CTC metastatic progression

Model: Cartilage

Application: Inflammation

Readout: Pro-inflammatory cytokine profile

Model: Gynecologic cancer

Application: PD, Efficacy

Readout: Dose response curve

Model: Vagina

Application: Hydration

Readout: Istology, immunohistochemistry, TEER.

Model: Cancer Joint

Application: Mode Of Action/Efficacy

Readout: Occurrence of CTC metastatic progression

Model: Cartilage

Application: Inflammation

Readout: Pro-inflammatory cytokine profile

LUNG
LIVER

Our lung models allow us to conduct comprehensive studies on safety, nanoparticle toxicity, and pollution effects. By mimicking the respiratory environment, we can evaluate how different substances interact with lung tissues, providing valuable insights into their potential health impacts.

By replicating the intricate liver architecture and its dynamic microenvironment, we can precisely assess drug metabolism and hepatotoxicity, helping to understand liver-specific responses and predicting potential side effects.

LUNG

Our lung models allow us to conduct comprehensive studies on safety, nanoparticle toxicity, and pollution effects. By mimicking the respiratory environment, we can evaluate how different substances interact with lung tissues, providing valuable insights into their potential health impacts.

Model: Lung

Application: Safety

Readout: Cytotoxicity

Model: Lung

Application: Nanoparticle Toxicity/Pollution

Readout: Cytotoxicity

LIVER

By replicating the intricate liver architecture and its dynamic microenvironment, we can precisely assess drug metabolism and hepatotoxicity, helping to understand liver-specific responses and predicting potential side effects.

Model: Liver

Application: Metabolism

Readout: Fraction of metabolized compound.

Model: Liver

Application: Safety

Readout: Hepato-Toxicity

Model: Liver Tumor

Application: PK/PD

Readout: Liver Off-Target Toxicity (IC50) And Anticancer On-Target Efficacy

Model: Lung

Application: Safety

Readout: Cytotoxicity

Model: Lung

Application: Nanoparticle Toxicity/Pollution

Readout: Cytotoxicity

Model: Liver

Application: Metabolism

Readout: Fraction of metabolized compound.

Model: Liver

Application: Safety

Readout: Hepato-Toxicity

Model: Liver Tumor

Application: PK/PD

Readout: Liver Off-Target Toxicity (IC50) And Anticancer On-Target Efficacy

MIVO CHIPS

ORGANS-on-CHIP

Explore our range of available Organ-On-Chip models & choose the one that best fits your research needs.

Choose your 3D model of human organs to recapitulate human physiology and disease in vitro.

We offer a wide selection of Organ-On-Chip models with living tissues that accurately mimic the in vivo environment of human organs. These models are ideal for long-term experiments and chronic disease studies.

Select the organ you wish to study in a fully humanized in vitro environment. If you don’t see the model you need, reach out to our team. Our R&D department is continually developing new models and may already be working on what you require!

In Our Laboratory

Supporting you with a testing service.

In Your Laboratory

Internal adoption of technology.

Work Together

Optimizing protocol assay for you.

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