Enhancing in vitro intestinal models: multi-compartmental organ-on-chip approach to investigate mucosal pathogen interactions
Human intestinal cell models play a crucial role in studying
various aspects of gastrointestinal biology and diseases: they are essential for investigating host-pathogen interactions and mechanisms behind inflammatory bowel diseases, evaluating drug absorption and exploring the effects of different treatments.
Furthermore, intestinal mucus lining the luminal surface, is crucial in defending the body against external insults and maintaining gut homeostasis. However, current in vitro models often lack representation of these key elements, limiting their applicability.
Our study aims to address this gap, through a co-culture
approach within a multi-compartmental organ-on-chip system to assess the efficacy of cells mucin secretion, barrier function over time, and their influence on bacterial adhesion.
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- Conference: Euroocs 2024, Milan
- Authors: E. Palama1, M. Aiello1,2, G. Borka1, S. Scaglione1,2
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1 React4life, Genoa – Italy
2 National Research Council (CNR)
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