A New Immunocompetent Platform For Modeling The 3D Tumor Microenvironment with Capillary Flow Driven Immune Cells
One of the most unmet challenges of microphysiological systems (MPS) is related to more predictive and fully humanized models for immune oncology o In vitro lack of physiological processes e g immune cell circulation extravasation infiltration of the tumor mass o In vivo Lack of fully humanized models o Compliance with 3 Rs principle.
- Conference: MPS World Summit 2021, Virtual Event
- Authors: Monica Marzagalli1, Fabrizio Fontana 2, Roberta Castriconi3,4, Cristina Bottino3,5, Silvia Scaglione1,6
1 React4life, Genoa – Italy
2 Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan – Italy
3 Department of Experimental Medicine, University of Genoa, Genoa – Italy
4 Centre of Excellence for Biomedical Research, CEBR, University of Genoa, Genoa – Italy
5 Laboratory of Clinical and Experimental Immunology, IRCCS Giannina Gaslini, Genoa – Italy
6 CNR IEIIT Institute, National Research Council of Italy, Genoa – Italy
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