A new immunocompetent OOC platform for modeling the 3D tumor microenvironment with capillary flow-driven immune cells
A novel Multi-In Vitro Organ (MIVO®) organ on a chip (OOC) platform has been adopted to culture immunocompetent human 3D tumor models, with circulating immune cells under fluid flow culture conditions resembling the in vivo conditions. The immune-cancer cells crosstalk has been widely investigated, opening new approaches for effectively testing novel immunomodulating agents in vitro.
One of the most unmet challenges of microphysiological systems (MPS) is related to more predictive and fully humanized in vitro models for immune-oncology.
The preclinical assessment of immunotherapies is currently carried out through too simplistic 2D cell culture in static conditions, and in vivo xenografts or genetically engineered animal models, generated by the engraftment of PDXs into immunodeficient mice bearing human immune cells, but cost, time, and complete immune-compatibility remain important challenges.
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- Conference: SLAS 2021, Virtual Event
- Authors: M. Marzagalli1, F. Fontana 2, A. Fedi3, M. Aiello1, R. Castriconi4, S. Scaglione1
1 React4life, Genoa – Italy
2 University of Milan – Italy
3 National Research Council, CNR-IEIIT – Italy
4 University of Genoa, DIMES – Italy
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