A human multi-organ and dynamic in vitro model for simultaneous and more predictive toxo-efficacy assays

In the oncology field, the need to address the poor success rate of clinical trials is becoming more and more evident. Therefore, the development of more predictive systems involving dynamic cues and organ-organ interactions is fundamental for evaluating the pharmacodynamic of novel anti-cancer treatments.
A novel multicompartmental and flexible organ-on-chip (OOC) platform has been adopted to fluidically connect a 3D ovarian cancer tissue to a hepatic cellular model, and to resemble the systemic cisplatin administration for investigating drug efficacy and contemporarily measuring potential hepatotoxic effects in a physiological context.

• • Conference:
  • Authors: Silvia Scaglione^1,2, C. Vitale³, A. Fedi^1,3, M. Fato³, M. Aiello^1,2