Thanks to the MIVO^® Esophagus-on-Chip, we obtained functional data on protective and reparative effects of our product under dynamic, tissue-like conditions—insights that could not be achieved with conventional static models and that provided clear answers on both mechanism of action and efficacy, proving valuable to our development strategy. In particular, we have been able to demonstrate that the reinforcement of defensive mechanisms and/o the protection of esophageal mucosa by a topical therapy as GSE Reflusolve Rapid may be a novel strategy to improve the management of GERD, particularly in patients refractory to PPIsteam