MIVO® DOUBLE FLOW
Double-side fluidic circulation
The fluid is able to flow through two different circuits both in the upper and in the lower chamber; different culture media can be fully managed (flow rate, ph, metabolic concentrations, and others). Both the upper and the lower fluid flow circuits are connected to a pump and their tubes blocked on the plate through the stoppers.
MIVO® Double Flow can be used in (performing) multiple tests, and adapted/adjusted in order to fit the best to your experiments. From the testimony of our customers and our experience, we propose the followings/some of this:
Drug toxicity and immunotherapies tests
MIVO® provides an in vitro system that can study the dynamics of drug effects in a more realistic way, mimicking a fisiological environment suitable for 3D cellular model subjected to mechanical stimuli and to the dynamic flow of the drug to be tested in terms of toxicity. At the same way, using mivo devices it is possible to test immunotherapies for cancer treatment with a more rliable and in-vivo like output.
Metastatic tumor assay
MIVO® device allows to host and cultivate epithelial tissues with the function of vascular wall to artificially recreate cell migration phenomena for the study of tumor metastasis onset and for the validation of new anticancer therapies. This innovative platform allows growing 3D cancer models for immediate, easy to perform and affordable in vitro drug testing.
Pulmonary air/liquid interface
Using the MIVO® device you can reproduce the pulmonary air/liquid interface (ALI) to study the pathophysiological mechanism of air pollutant mediated pulmonary toxicity. Mivo can be a realistic and efficient platform for lung toxicity tests following the exposure to a dynamic flow of aerosolized or gaseous form of air pollutants.
