A novel multi-organ model for performing more reliable preclinical toxo-efficacy assays

Multiple human disorders display unknown tissues relationships affecting disease progression and drugs response1. While current in vitro assays fail in recapitulating organ-organ connection, animal models reveal species-specific drug outcomes.

To this purpose, a novel fully humanized multi-organ on chip device (MIVO^®) has been adopted to fluidically connect 3D ovarian cancer tissues with a hepatic cellular model, recapitulate the systemic administration of drugs (i.e. cisplatin) and simultaneously investigate both its anticancer efficacy and potential hepatotoxic effect.