Multiple human disorders display unknown tissues relationships affecting disease progression and drugs response1. While current in vitro assays fail in recapitulating organ-organ connection, animal models reveal species-specific drug outcomes.

To this purpose, a novel fully humanized multi-organ on chip device (MIVO®) has been adopted to fluidically connect 3D ovarian cancer tissues with a hepatic cellular model, recapitulate the systemic administration of drugs (i.e. cisplatin) and simultaneously investigate both its anticancer efficacy and potential hepatotoxic effect.

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