3D custom tumour models

React4Life cancer experts develop novel 3D cell laden tumor models customized to various projects and requirements, by adopting a biology-driven patented technological solution.
These 3D tumor models can be both cultured under static conditions and under fluid-dynamic stimuli under MIVO® for prolonged time and the viability, proliferation and migration of cells assessed. Once established, the platform can be used for your needs.

In the paper “Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies”, the team describes a Clinical-Relevant reliable 3D neuroblastoma Model towards immunotherapies testing. Treatment failures of Neuroblastoma (NB) are mainly due to the lack of adequate in vitro models for studying the efficacy of potential therapeutics, including those aimed to enhance anti-tumor immune responses. This study published in Frontiers in Immunology shows a 3D cell laden hydrogel as tumor model to evaluate the effects of the three-dimensionality on biological and immunological properties of NB cells. This 3D model highlighted molecular features that more closely resemble the immunophenotypic variants occurring in vivo and not fully appreciated in classical 2D culture conditions.

Discover more here: Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies.

Get Started!