Growing 2D cell cultures outside their natural system in an artificially created microenvironment has been the gold standard for decades. These models were used to setup predictable and reproducible in-vitro models to test scientists’ experimental hypothesis, mostly due to their ease of use and low cost.
However, real tissues are made of cells in a 3D conformation, and everything that happens to any given cell is not just a result of a 2D exchange, but of a multitude of interactions, from biological to mechanical, all combining to produce a specific message to the cell. Moreover, human environment is intrinsically fluidic, specifically fluid-dynamic. With MIVO technology, a new era in the 3D fluido-dynamic human tissue culture can start.