Research and Development

Growing 2D cell cultures outside their natural system in an artificially created microenvironment has been the gold standard for decades. These models were used to setup predictable and reproducible in-vitro models to test scientists’ experimental hypothesis, mostly due to their ease of use and low cost.

However, real tissues are made of cells in a 3D conformation, and everything that happens to any given cell is not just a result of a 2D exchange, but of a multitude of interactions, from biological to mechanical, all combining to produce a specific message to the cell. Moreover, human environment is intrinsically fluidic, specifically fluid-dynamic. With MIVO technology, a new era in the 3D fluido-dynamic human tissue culture can start.

MIVO® is the first product of React4life for in vitro testing. It is a technology combining 3D human tissue and fluidic system to mimic physiological organ with the highest reliability. Thanks to this technology, React4life help scientific community to:

  • Drastically reduce animal experiments
  • Reduce R&D testing costs, since promising drugs are identified earlier
  • Make easier and faster the testing assays, since MIVO® is storable, ready-to-use and flexible

React4life team is hardly working to new approaches for the cancer treatment research. Thanks to our international partners, MIVO® product has been already adopted for drug efficacy test against ovarian cancer, and for immuno-therapies testing against neuroblastoma paediatric cancer.

Our projects

Breast to Bone

This project is a Future Emerging Technology (FET) receiving funding from the European Union’s Horizon 2020 research and innovation programme under the grant agreement No 801159. Its title is: “modeling spontaneous breast cancer metastasis to the bone with a first-of-its-kind 3d device that recapitulates physiological tissue-level complexity”

SME Instrument

React4life has got funding and support from the European Union’s Horizon 2020 (grant agreement No 827655) for breakthrough innovation projects with a market-creating potential under revamped SME instrument, which is rolled out as part of the European Innovation Council (EIC) pilot. The SME instrument will boost fast company growth and market-creating innovation thanks to staged funding and ramped up business acceleration services.


React4life with the Monzino Cardiological Institute and the National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ has obtained funding from the European Union and the Lombardy Region from the 1st Fesr Association 2014-2020 for the Cardio-Cov project: “Effects of COVID-19 infection on inflammation and cardiac fibrosis. In vitro modeling “.

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