The revolution: Multi-Organ On Device (MOOD)
The lack of suitable accredited organ models makes it impossible to perform scientifically reliable, controlled and reproducible tests on molecules and compounds generally that interact with the human body.
This problem is felt in various biotech sectors, each of which bases its own testing phase on the following approaches:
In the biotech scenario, the most widely used approaches for in vitro testing include the use of 2D systems, Petri dishes or slides, and animal models. The first method is unreliable mainly because the 2D conditions do not correspond to the tridimensionality of the human body; the second presents other disadvantages: among the best known, the differences between man and animal, high experimental costs and ethical issues. For molecular or drug diffusion studies, Transwell are commonly used; Transwell have predetermined size, non-replaceable membranes and, in general, are far from a physiological 3D context, being mostly represented by a monolayer of cells.
Our technology wants to fill these gaps, finally conducting to more realistic and reliable tests. Multi-Organ On Device (MOOD) is a patented technology developed to model physiological barriers in vitro.
MOOD consists in a fluid-dynamic, multi-chamber culture system where it is possible to test, just by varying the interfacing membrane and the parameters of the system:
– drug efficacy
– cosmetics absorption and transdermal diffusion
– nutrient digestibility
– in general, all those processes taking place at interfaces.
MOOD can accommodate commercial 3D equivalent tissues, biopsies of different shape and thickness or artificial membranes moving towards the concept of personalized medicine.
Among these, React4life can provide a broad range of membrane models including polymeric electrospun membranes and 3D printed membranes.
MOOD allows observing the tissues and cells cultured within, under a traditional inverted microscope.