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So far Giulia Piaggio has created 75 blog entries.

A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo

2020-04-16T13:36:28+00:00

The team describes a 3D breast tumor model cultured within the multi in vitro organ device Breast cancer is the most common cancer in women and one of the leading causes of cancer related deaths worldwide. Mortality is mainly associated with the development of metastases, the spread of a tumor from its primary site [...]

A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo2020-04-16T13:36:28+00:00

Green-reduced graphene oxide induces in vitro an enhanced biomimetic mineralization of polycaprolactone electrospun meshes

2020-04-01T09:52:49+00:00

The team describes an electrospun mesh as permeable porous model A novel green method for graphene oxide (GO) reduction via ascorbic acid has been adopted to realize bio-friendly reduced graphene oxide (RGO)/polycaprolactone (PCL) nanofibrous meshes, as substrates for bone tissue engineering applications. PCL fibrous mats enriched with either RGO or GO (0.25 wt%) were fabricated [...]

Green-reduced graphene oxide induces in vitro an enhanced biomimetic mineralization of polycaprolactone electrospun meshes2020-04-01T09:52:49+00:00

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

2020-04-01T10:25:27+00:00

The team describes a bioreactor for cardiac applications Cardiovascular diseases still represent the leading cause for morbidity and mortality in the western world, giving rise to many disabilities in patients. Current clinical regimens largely rely on the use of drugs, medical devices and changes in lifestyle but, despite large beneficial outcomes, none of these [...]

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases2020-04-01T10:25:27+00:00

Design and development of a 3D fluidic bioreactor platform for a combined mechanical/perfusing stimulation of articular substitutes

2020-04-01T10:26:49+00:00

A. Marella, V. Alberi, S. Scaglione describes a 3D fluidic bioreactor platform for articular tissue applications Due to its avascular nature, articular cartilage exhibits a very limited capacity to regenerate and to repair. Although much of the engineered cartilage grafts so far proposed have successfully shown to mimic the morphological and biochemical appearance of [...]

Design and development of a 3D fluidic bioreactor platform for a combined mechanical/perfusing stimulation of articular substitutes2020-04-01T10:26:49+00:00

Microenvironment complexity and matrix stiffness regulate breast cancer cells activity in a 3D in vitro model

2020-04-01T11:47:39+00:00

Cavo M, Fato M, Peñuela L, Beltrame F, Raiteri R, Scaglione S, describes a 3D cell laden breast cancer model Mechanical stimuli from the cell microenvironment play a key role in affecting several types of cell behaviour, both in healthy and in pathological conditions. In particular, cells sense their microenvironment via trans-membrane proteins and consequently regulate several physiological processes such [...]

Microenvironment complexity and matrix stiffness regulate breast cancer cells activity in a 3D in vitro model2020-04-01T11:47:39+00:00

Improved cell activity on biodegradable photopolymer scaffolds using titanate nanotube coatings

2020-04-01T12:10:35+00:00

The team describes a nanocoating of surfaces for improved cell activity The development of bioactive materials is in the premise of tissue engineering. For several years, surface functionalization of scaffolds has been one of the most promising approaches to stimulate cellular activity and finally improve implant success. Herein, we describe the development of a [...]

Improved cell activity on biodegradable photopolymer scaffolds using titanate nanotube coatings2020-04-01T12:10:35+00:00

Oriented collagen nanocoatings for tissue engineering

2020-04-01T12:19:10+00:00

The team describes the collagen-based functionalization of substrates for enhanced cellular response   Collagens are among the most widely present and important proteins composing the human total body, providing strength and structural stability to various tissues, from skin to bone. In this paper, we report an innovative approach to bioactivate planar surfaces with oriented [...]

Oriented collagen nanocoatings for tissue engineering2020-04-01T12:19:10+00:00

Mesenchymal stem cell culture in convection-enhanced hollow fibre membrane bioreactors for bone tissue engineering

2020-04-01T12:49:22+00:00

The team describes the use of bioreactors for bone tissue engineering applications   Preparation of tissue engineered bone constructs to repair large size defects is limited by the difficult supply of oxygen and nutrients to cells deep inside the constructs. Hollow fibre membrane bioreactors (HFMBs) with medium flowing in membrane lumen have structural and [...]

Mesenchymal stem cell culture in convection-enhanced hollow fibre membrane bioreactors for bone tissue engineering2020-04-01T12:49:22+00:00

Bioactive TGF-β1/HA alginate-based scaffolds for osteochondral tissue repair: design, realization and multilevel characterization

2020-04-01T12:50:51+00:00

The team describes the alginate-based hydrogels as osteochindral tissue model The design of an appropriate microenvironment for stem cell differentiation constitutes a multitask mission and a critical step toward the clinical application of tissue substitutes. With the aim of producing a bioactive material for orthopedic applications, a transforming growth factor-β (TGF- β1)/hydroxyapatite (HA) association [...]

Bioactive TGF-β1/HA alginate-based scaffolds for osteochondral tissue repair: design, realization and multilevel characterization2020-04-01T12:50:51+00:00

Effects of fluid flow and calcium phosphate coating on human bone marrow stromal cells cultured in a defined 2D model system

2020-04-01T12:55:07+00:00

The team describes the effect of shear stress induced fluid flow on stem cell differentiation In this study, we investigated the effect of the long-term (10 days) application of a defined and uniform level of fluid flow (uniform shear stress of 1.2 x 10(-3) N/m(2)) on human bone marrow stromal cells (BMSC) cultured on [...]

Effects of fluid flow and calcium phosphate coating on human bone marrow stromal cells cultured in a defined 2D model system2020-04-01T12:55:07+00:00