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About Giulia Piaggio

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So far Giulia Piaggio has created 73 blog entries.

Join our free webinar “3D human tissues and fluid-dynamic Multi-In Vitro Organ-MIVO device for in vitro testing”, Tuesday 19th May at 2:30 pm

2020-05-12T08:57:32+00:00

Are organoids and organ-on-chip the future of scientific research? With the right technology the answer is yes! Our CSO, Silvia Scaglione, introduces in this webinar the potentiality of the React4life’s patented core technologies MIVO, the fluid-dynamic multi-chamber device that allows to recreate in lab human complex systems for improving the in vitro 3D tissue [...]

Join our free webinar “3D human tissues and fluid-dynamic Multi-In Vitro Organ-MIVO device for in vitro testing”, Tuesday 19th May at 2:30 pm2020-05-12T08:57:32+00:00

To each his own therapy. Organoids, test in vitro and MIVO devices to test specific treatments suggested by our own cells

2020-04-24T08:11:09+00:00

The technology allows us to use the so-called organoids, three-dimensional (3D) structures formed by the cells extracted from the patient himself, for in vitro tests aimed at identifying the most effective drug. Everyone is talking about personalized medicine very often, but what exactly does it mean, and how could it be possibly implemented? The [...]

To each his own therapy. Organoids, test in vitro and MIVO devices to test specific treatments suggested by our own cells2020-04-24T08:11:09+00:00

Primary cells are used in ADME and toxicology studies. Let’s find out how and why.

2020-04-06T13:41:42+00:00

The main difference between primary cells and tumor cell lines is that the first are isolated directly from healthy human or animal tissues while others have normal diploid chromosomes and maintain much of the physiological properties of the tissue from which they are derived. During drug development, and before ever administering a new drug [...]

Primary cells are used in ADME and toxicology studies. Let’s find out how and why.2020-04-06T13:41:42+00:00

The demand of anti-pollution beauty products is growing in 2020

2020-03-31T07:56:40+00:00

The beauty products with anti-pollution battling skin care are on the rise in markets. The increasing pollution levels, the deteriorating air quality, the depleting ozone layer and wider climate concerns, have all caused a huge shift in consumers’ attitude over the past few years. This is one of some reason that reflected in the [...]

The demand of anti-pollution beauty products is growing in 20202020-03-31T07:56:40+00:00

How is the study on the evaluation of alternative methods to animal testing going?

2020-03-27T10:44:35+00:00

In Europe there is a commission, the EURL ECVAM which is an integral part of the JRC, JOINT RESEARCH CENTER which is located in Ispra, Italy. The mandate of EURL ECVAM is reported in the EU legislation relating to the protection of animals used in laboratories for scientific purposes. The purpose of the ECVAM [...]

How is the study on the evaluation of alternative methods to animal testing going?2020-03-27T10:44:35+00:00

A three-dimensional traction/torsion bioreactor system for tissue engineering

2020-04-01T12:56:57+00:00

The team describes the use of bioreactors for ligament tissue engineering applications The aim of this study was to design, develop and validate a simple, compact bioreactor system for tissue engineering. The resulting bioreactor was designed to achieve ease-of-use and low costs for automated cell-culturing procedures onto three-dimensional scaffolds under controlled torsion/traction regimes. Highly [...]

A three-dimensional traction/torsion bioreactor system for tissue engineering2020-04-01T12:56:57+00:00

Engineering of osteoinductive grafts by isolation and expansion of ovine bone marrow stromal cells directly on 3D ceramic scaffolds

2020-04-01T13:00:30+00:00

The team describes the effect of perfused fluid flow for generating osteogenic grafts In this work, we investigated whether osteoinductive constructs can be generated by isolation and expansion of sheep bone marrow stromal cells (BMSC) directly within three-dimensional (3D) ceramic scaffolds, bypassing the typical phase of monolayer (2D) expansion prior to scaffold loading. Nucleated [...]

Engineering of osteoinductive grafts by isolation and expansion of ovine bone marrow stromal cells directly on 3D ceramic scaffolds2020-04-01T13:00:30+00:00

In vitro demonstration of intestinal absorption mechanisms of different sugars using 3D organotypic tissues in a fluidic device

2020-04-01T13:13:32+00:00

The team describes the use of MiVO in combination with 3D human intestinal tissues for highly reliable in vitro intestinal permeation tests Intestinal permeability is crucial in regulating the bioavailability and the biological effects of drugs and compounds. However, systematic and quantitative studies of absorption of molecules are quite limited due to the lack [...]

In vitro demonstration of intestinal absorption mechanisms of different sugars using 3D organotypic tissues in a fluidic device2020-04-01T13:13:32+00:00

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

2020-04-01T13:16:37+00:00

The team describes a Clinical-Relevant reliable 3D neuroblastoma Model towards immunotherapies testing    Neuroblastoma (NB) represents an aggressive, metastatic solid tumors of childhood, with a very poor survival rate, despite the use of combination therapies including novel immunotherapies. Treatment failures are mainly due to the lack of adequate in vitro models for studying the efficacy of [...]

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies2020-04-01T13:16:37+00:00

A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo

2020-04-16T13:36:28+00:00

The team describes a 3D breast tumor model cultured within the multi in vitro organ device Breast cancer is the most common cancer in women and one of the leading causes of cancer related deaths worldwide. Mortality is mainly associated with the development of metastases, the spread of a tumor from its primary site [...]

A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo2020-04-16T13:36:28+00:00