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About Giulia Piaggio

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So far Giulia Piaggio has created 43 blog entries.

Primary cells are used in ADME and toxicology studies. Let’s find out how and why.

2020-04-06T13:41:42+00:00

The main difference between primary cells and tumor cell lines is that the first are isolated directly from healthy human or animal tissues while others have normal diploid chromosomes and maintain much of the physiological properties of the tissue from which they are derived. During drug development, and before ever administering a new drug [...]

Primary cells are used in ADME and toxicology studies. Let’s find out how and why.2020-04-06T13:41:42+00:00

The demand of anti-pollution beauty products is growing in 2020

2020-03-31T07:56:40+00:00

The beauty products with anti-pollution battling skin care are on the rise in markets. The increasing pollution levels, the deteriorating air quality, the depleting ozone layer and wider climate concerns, have all caused a huge shift in consumers’ attitude over the past few years. This is one of some reason that reflected in the [...]

The demand of anti-pollution beauty products is growing in 20202020-03-31T07:56:40+00:00

How is the study on the evaluation of alternative methods to animal testing going?

2020-03-27T10:44:35+00:00

In Europe there is a commission, the EURL ECVAM which is an integral part of the JRC, JOINT RESEARCH CENTER which is located in Ispra, Italy. The mandate of EURL ECVAM is reported in the EU legislation relating to the protection of animals used in laboratories for scientific purposes. The purpose of the ECVAM [...]

How is the study on the evaluation of alternative methods to animal testing going?2020-03-27T10:44:35+00:00

A three-dimensional traction/torsion bioreactor system for tissue engineering

2020-04-01T12:56:57+00:00

The team describes the use of bioreactors for ligament tissue engineering applications The aim of this study was to design, develop and validate a simple, compact bioreactor system for tissue engineering. The resulting bioreactor was designed to achieve ease-of-use and low costs for automated cell-culturing procedures onto three-dimensional scaffolds under controlled torsion/traction regimes. Highly [...]

A three-dimensional traction/torsion bioreactor system for tissue engineering2020-04-01T12:56:57+00:00

Engineering of osteoinductive grafts by isolation and expansion of ovine bone marrow stromal cells directly on 3D ceramic scaffolds

2020-04-01T13:00:30+00:00

The team describes the effect of perfused fluid flow for generating osteogenic grafts In this work, we investigated whether osteoinductive constructs can be generated by isolation and expansion of sheep bone marrow stromal cells (BMSC) directly within three-dimensional (3D) ceramic scaffolds, bypassing the typical phase of monolayer (2D) expansion prior to scaffold loading. Nucleated [...]

Engineering of osteoinductive grafts by isolation and expansion of ovine bone marrow stromal cells directly on 3D ceramic scaffolds2020-04-01T13:00:30+00:00

In vitro demonstration of intestinal absorption mechanisms of different sugars using 3D organotypic tissues in a fluidic device

2020-04-01T13:13:32+00:00

The team describes the use of MiVO in combination with 3D human intestinal tissues for highly reliable in vitro intestinal permeation tests Intestinal permeability is crucial in regulating the bioavailability and the biological effects of drugs and compounds. However, systematic and quantitative studies of absorption of molecules are quite limited due to the lack [...]

In vitro demonstration of intestinal absorption mechanisms of different sugars using 3D organotypic tissues in a fluidic device2020-04-01T13:13:32+00:00

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

2020-04-01T13:16:37+00:00

The team describes a Clinical-Relevant reliable 3D neuroblastoma Model towards immunotherapies testing    Neuroblastoma (NB) represents an aggressive, metastatic solid tumors of childhood, with a very poor survival rate, despite the use of combination therapies including novel immunotherapies. Treatment failures are mainly due to the lack of adequate in vitro models for studying the efficacy of [...]

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies2020-04-01T13:16:37+00:00

A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo

2020-04-01T10:06:45+00:00

The team describes a 3D breast tumor model cultured within the multi in vitro organ device Breast cancer is the most common cancer in women and one of the leading causes of cancer related deaths worldwide. Mortality is mainly associated with the development of metastases, the spread of a tumor from its primary site [...]

A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo2020-04-01T10:06:45+00:00

Green-reduced graphene oxide induces in vitro an enhanced biomimetic mineralization of polycaprolactone electrospun meshes

2020-04-01T09:52:49+00:00

The team describes an electrospun mesh as permeable porous model A novel green method for graphene oxide (GO) reduction via ascorbic acid has been adopted to realize bio-friendly reduced graphene oxide (RGO)/polycaprolactone (PCL) nanofibrous meshes, as substrates for bone tissue engineering applications. PCL fibrous mats enriched with either RGO or GO (0.25 wt%) were fabricated [...]

Green-reduced graphene oxide induces in vitro an enhanced biomimetic mineralization of polycaprolactone electrospun meshes2020-04-01T09:52:49+00:00

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

2020-04-01T10:25:27+00:00

The team describes a bioreactor for cardiac applications Cardiovascular diseases still represent the leading cause for morbidity and mortality in the western world, giving rise to many disabilities in patients. Current clinical regimens largely rely on the use of drugs, medical devices and changes in lifestyle but, despite large beneficial outcomes, none of these [...]

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases2020-04-01T10:25:27+00:00