In vitro dermal absorption tissue studies are performed within MIVO with porcine biopsies or 3D reconstructed human epidermis.
Test formulations are applied to the upper surface and their concentration are measured at pre-determined time points from the reservoir chamber. The biological effects of the test compound on the skin can be also assessed. Skin studies are used to assess the feasibility of transdermal administration, to rank-order compounds in terms of permeability or accumulation, and to optimize formulations.
We are currently seeking a Cell Biologist, to be included in React4life R&D team; the successful candidate will work on in vitro 3D tissue cultures, disease models and fluid-dynamic culture.
He/she will serve as a driver of business development, driving adoption of new products and innovation.
The applicant must have a Ph.D. or equivalent doctoral degree in a field related to the topic, with significant laboratory experience.
This role requires an individual with a proven track record in research, combined with the ability to manage team and resolve technical issues.
Research experience in tumor cell lines and primary cell manipulation, 3D-organoids culture, immunostaining, cells migration assay, cell viability and proliferation, metabolic assay is strongly preferred.
Background in cancer biochemistry, drug discovery, cytotoxicity will be considered favorably.
The Following Skills Would Be Advantageous:
Ability to work on tight deadlines with a sense of urgency.
Experience with SOPs when performing lab functions, maintaining paperwork and batch records, but also to work independently as required.
Strong problem-solving attitude.
Ability to disseminate scientific results (papers, conferences,..)
Demonstrated proficiency with computer applications, including MS Word, Excel, Outlook, PowerPoint.
In the marvelous city of Naples, Italy, sponsored by Confindustria and with participation of political authorities, 4th and 5th November, it took place the ITWIIN, an initiative of the association of inventive and innovative women that promotes and assists innovative female projects.
A great success for Silvia, and for React4life, with the first award “2019 best inventor”. Silvia presented MIVO, our worldwide patented technology applied in various sectors, through which it is possible to reproduce in the laboratory living organs for testing purposes (oncology, pharmacology, nutraceutical, dermocosmetic).
What is ITWIIN?
ITWIIN is an association of inventive and innovative women who aims to help other women with ideas and innovations to achieve their aspirations, improve self-esteem and motivation and broaden horizons and experiences. The Association aims to bring together different professionals and experiences of women in Italy and in Europe in different sectors: from intellectual property rights, trademarks and patents, to industrial and academic research, to technology transfer.
ITWIIN operates in contact with other associations active in the same fields and acts as a link to facilitate and promote dialogue with Italian and European institutions. In this sense it is included in the European network of inventive and innovative women, EUWIIN.
“The combination of 3D human cancer tissues and fluid-dynamic drug administration as winning strategy for in vitro drug efficacy testing”, A.Marrella, M.Aiello, C.Degrassi, S. Scaglione – Short Presentations 3D models & multi-organ-chips, Thursday, October 10, 2019 at 13:55 – 15:25 (14:55 – 15:10)
In vitro demonstration of different intestinal absorption mechanisms of lactulose and mannitol by using 3D tissue inserts within fluidic multi-chamber devices A.Marrella, P.Buratti, J.Markus, G.Firpo, S.Ayehunie, S.Scaglione, H. Kandarova, M.Aiello | Short Presentations Advanced safety testing of cosmetics & consumer products and alternatives to animal testing in food safety, nutricion and efficacy, Saturday, October 12, 2019 at 15:30 – 17:00 (16:45 – 17:00)
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